Traditional TCR discovery is slow, expensive, and often yields limited success. After enduring labor-intensive processes such as gene synthesis, viral vector manufacturing, cell engineering, and reactivity testing, researchers frequently find that too few—or none—of the tested candidates exhibit the desired functionality.
At RootPath, we redefine TCR discovery by dramatically increasing the throughput of TCR characterization, enabling exploration of a much wider sequence space. As highlighted in our landmark paper in Nature Biotechnology, we synthesize and functionally test hundreds to thousands of TCRs simultaneously, offering this service at an affordable cost while shortening project timelines from months to just weeks.
Join us to discover therapeutic TCRs at scale!